Biostatistical methods by Stephen W. Looney

By Stephen W. Looney

Univ. of Louisville, KY. Applies biostatistics to the learn of genetics and the factors and remedy of disorder. Covers contemporary advancements in picture quantitation, microarrays, and proteomics. Discusses using info administration software program. comprises a number of information units and software program options.

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This page intentionally left blank PART I THE PRESENT This page intentionally left blank POLIO: PRESENT STATUS AND POST-ERADICATION POLICIES Daniel Tarantola 1 partners towards poliomyelitis eradication, has reminded us that interrupting polio transmission must remain our top priority (1). Since the polio eradication initiative was launched in 1988, the number of polio cases has been drastically reduced from the more than 350,000 cases reported that year. As of November 2002, for example, reported cases had dropped to 1,100, representing a greater than 99% reduction.

Associated with the post-certification era are the options for stopping the use of OPV. These are real challenges during both pre- and postcertification periods, and yet it is important to highlight them at this juncture as a reminder that we will have to live with these activities and sustain them at very high standards for a number of years. The last occurrence of polio transmission will not signify the interruption of these activities, which, on the contrary, will need to continue for a number of years into the future.

Such individuals could form the focus of an epidemic if those around them are not immunized and if they fail to follow good hygienic practices. Treatments attempted on the British subject have included the administration of immunoglobulin by the oral route, which appeared to have some effect on the titer of virus excreted in the stools. Chemotherapeutic agents are not well established for such patients, although some have been considered. The virus excreted is resistant to the most commonly considered drug.

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