By Jannie Borst, Lex Bakker, Ferry Ossendorp (auth.), W. Clark Lambert, Benvenuto Giannotti, Willem A. van Vloten (eds.)
This ebook relies upon a chain of papers initially offered at a NATO complicated experiences Workshop of a similar identify held on the learn heart hello Cappuccini," a switched over monastery in San Miniato, a small village positioned among Pisa and Florence, Italy, in October 1991. Authors have been requested to put up their accomplished chapters through the subsequent February; those have been then scanned onto laptop disks, edited and back to the authors for ultimate revision, and updating, with a last cut-off date of February 1993. The authors have been inspired to make no matter what ameliorations they sought after, specially relating to updating their chapters, with a watch to creating the ultimate product either complete and present. during this we succeeded past our expectancies, with so much chapters broadly altered and plenty of thoroughly re-written and considerably increased. hence, even though the unique assembly used to be held in 1991, the chapters during this quantity should be considered as present from no less than February, 1993, with many of the ultimate up-to-date revisions bought as past due as July, 1993. This booklet, as agreed in our unique agreement, has been brought to the writer "camera-ready. " which means the entire scanning, modifying, proofing and typesetting have been performed the following, by way of the place of work of the dept of Dermatology on the New Jersey scientific college. We primarily produced the publication, which the writer, for the main half, then photocopied. This has been a major burden, borne generally by way of my colleague during this department, Robert A.
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Additional info for Basic Mechanisms of Physiologic and Aberrant Lymphoproliferation in the Skin
Breathnach SM and SI Katz, 1984. marrow-derived. J. Invest. , 94:37-42. Thy-l + dendritic cells in murine epidermis are bone J. Invest. , 83:74-77. Dupuy P, M Heslan, S Fraitag, T Hercend, L Dubertret and M Bagot, 1990. receptor-'Y/o bearing lymphocytes in normal and inflammatory human skin. T-cell J. Invest. , 94:764-768. Dustin ML, KH Singer, DT Tuck and TA Springer, 1988. Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon-'Y and is mediated by intercellular adhesion molecule 1 (ICAM-l).
1982). These and other observations have led investigators to postulate that Langerhans cells may be involved in providing signals that promote the expansion of malignant cells (Figure 1, LC-TM1). On the other hand, the malignant clone may grow autonomously, and the TIL's may receive their stimulatory signal through the APC's (Figure 1, LC-TIL). The stimulatory signal could include antigenic peptides derived from the malignant clone. CD36+ LC with Convoluted Nuclei We have found increasing evidence that Langerhans cells in the lesions of mycosis fungoides-type CTCL have acquired a modified phenotype and functional program.
06% of Thy-l+ cells, in 6 week old C57BU6 nu/nu mice. With advancing age of these animals, the absolute numbers of CD3 + cells, as well as their percentage among Thy-l + cells, continuously increased. In 12 month old nude animals, up to 3 % of all Thy-l + cells reacted with the anti-CD3 mAb. Phenotypic examination of CD3 + epidermal cells of athymic mice, as well as of lines derived from these cells, indicated that the nude mouse epidermal T cells are similar to DETC in that they are Thy-l +, CD45+, asialo GMI +, CD5-, CD4- and predominantly CD8-.