Antiarrhythmic Drugs by E. M. Vaughan Williams (auth.), E. M. Vaughan Williams

By E. M. Vaughan Williams (auth.), E. M. Vaughan Williams Professor Dr. (eds.)

The improvement of a brand new antiarrhythmic drug contains many folks with disparate abilities. The natural chemist who makes it's guided not just by means of the structure-action family of prior compounds, yet by means of anticipation of a demand for a specific kind of motion. in truth a number of of the best-known antiarrhythmics, together with lidocaine, mexiletine, amiodarone and verapamil, have been initially synthesized for different reasons. Physicians need to confirm even if the recent drug works, and pharma­ cologists the way it works. For a few years i've got believed that there has been room for a piece that can be understood via a majority of these teams and which can enlighten each one in regards to the viewpoint of the others. therefore while i used to be invited by way of Springer-Verlag to organize a quantity of their sequence guide of Experimental Pharmacology, I already had an organization belief of what its shape can be. In any multi-author paintings there are goals which can't constantly simply be reconciled. the 1st is to pick issues which might relate to one another in a coherent demeanour. to provide a logical and orderly form to the amount as an entire. the second one is to provide authors the best attainable freedom to specific themselves as they want. while the final layout used to be entire, potential members have been invited to put in writing particular chapters, being supplied with an entire record in their coauthors and selected issues, in order that they may keep away from overlap.

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5 V) that of the source (3 V), so that a pair of electrodes placed anywhere along this line would record nothing. This illustrates one axiom of electrocardiography: 1. No signal is recorded from electrodes situated at right angles to the axis of the source. If a pair of bipolar electrodes were positioned in the fluid to the east of the source, as illustrated in Fig. 5 b, the more northerly of the pair would be nearer to the negative pole of the battery and so would be negative relative to the other.

1 '" . •... . !.. ::::::::::/ 5 5 7 a i~:;~:::) .. ~ -. :. 8 b 6 6 12 3 9 d 6 Vector angle unchanged 9 5 7 c e VAUGHAN WILLIAMS f 6 3 Cardiac Electrophysiology 9 45). IncidentallY,half of the information in Fig. 5 f is redundant, because the positive and negative records are mirror images. If electrodes were placed, as in Fig. 5 V. If the upper battery were reversed, as in Fig. 5 V, negative inside, but no current would flow in the dish, because both ends of the battery would be at the same (positive) voltage.

On the right, the epicardial APD is shown as shorter than the endocardial APD, which makes the depolarization and repolarization vectors concordant in sign 18 E. M. VAUGHAN WILLIAMS might even become discordant, if the endocardial action potential duration (APD) became as short as the epicardial APD. If, however, it was the epicardium·which became ischaemic, the epicardial APD would become even shorter than before, so that the height of the concordant T wave would be increased. If invasion of the ventricle is slowed the QRS complex widens and the Q-T interval will accordingly be prolonged.

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