Advances in Understanding Kingella kingae by Joseph W. St. Geme III

By Joseph W. St. Geme III

This publication describes the turning out to be physique of knowledge at the epidemiology, medical manifestations, transmission, pathogenesis, analysis, and therapy of Kingella kingae infectionsin children. furthermore, it covers experimental tools which were built to review the microbiology, genetics, and virulence components of K. kingae, details that gives the basis for brand spanking new methods to therapy and prevention of K. kingae disease. With this content material in brain, excerpts from the ebook may be of relevance for clinicians who deal with pediatric sufferers, for medical microbiologists who're curious about detecting organisms in scientific specimens, and for scientists who're learning K. kingae in an attempt to strengthen novel objectives for antimicrobial treatment and new ways to prevention.

First remoted within the Sixties via Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae was once principally missed over the following twenty years as a human pathogen due to its unusual restoration from sufferers with disorder. in spite of the fact that, lately K. kingae has been more and more famous as a clinically vital pathogen in young ones, and is at present well-known because the major reason for osteoarticular infections in youngsters in progressively more international locations. study into this organism has grown enormously during the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of illness.

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Basmaci R, Lorrot M, Bidet P, Doit C, Vitoux C, Pennecot G, Mazda K, Bingen E, Ilharreborde B, Bonacorsi S (2011) Comparison of clinical and biologic features of Kingella kingae and Staphylococcus aureus arthritis at initial evaluation. Pediatr Infect Dis J 30 (10):902–904. 0b013e31821fe0f7 39. Mallet C, Ceroni D, Litzelmann E, Dubois-Ferriere V, Lorrot M, Bonacorsi S, Mazda K, Ilharreborde B (2014) Unusually severe cases of Kingella kingae osteoarticular infections in children. Pediatr Infect Dis J 33(1):1–4.

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Ann Lab Med 34(4):313–316. 313 40. Cherkaoui A, Ceroni D, Emonet S, Lefevre Y, Schrenzel J (2009) Molecular diagnosis of Kingella kingae osteoarticular infections by specific real-time PCR assay. J Med Microbiol 58(Pt 1):65–68. 47707-0 41. Lehours P, Freydiere AM, Richer O, Burucoa C, Boisset S, Lanotte P, Prere MF, Ferroni A, Lafuente C, Vandenesch F, Megraud F, Menard A (2011) The rtxA toxin gene of Kingella kingae: a pertinent target for molecular diagnosis of osteoarticular infections. J Clin Microbiol 49(4):1245–1250.

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