A History of Diabetes in Pregnancy: The impact of maternal by Harold Kalter

By Harold Kalter

Type 1 diabetes is a significant and customary affliction, afflicting one in step with 2 hundred of the inhabitants around the world. it truly is greatly believed to reason damaging actual maldevelopment--congenital malformations--and different outcomes within the unborn young children of girls with the illness. This e-book considers the historical past of the ailment in pregnant girls and this trust that it explanations anomalies because the time of the invention of insulin in 1921, and provides a profound and demanding appraisal of the topic of its meant prenatal harmfulness.

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Additional resources for A History of Diabetes in Pregnancy: The impact of maternal diabetes on offspring prenatal development and survival

Example text

The latter, diabetes appearing or discovered for the first time during pregnancy, the subject here, was given the name gestational diabetes by O’Sullivan (1961). He explained that it referred to an asymptomatic condition signaled by blood glucose concentrations lying between a borderline area at the upper reaches of normality on the one hand and unequivocal diabetes on the other. [An aside: Before the new name was introduced diabetic pregnancies of pregestational origin not requiring insulin were denoted class A (White 1949).

In many studies the women were pregnant or recently pregnant. This was an important point. A new fashion—the prospective approach—was then turned to, and many prediabetic pregnant women, 20-40%, especially those that had had big babies, when glucose tolerance tested, responded abnormally (see Engleson and Lindberg 1962). Even in the first such study certain maternal attributes were associated with big babies (Gilbert 1949), one of the major ones, as suspected, being obesity; though of 40 6 Prediabetes course the analysis was confounded by many later discovered variables (see Larsson et al.

To summarize, severity was estimated or classified by two criteria: duration and extent of vascular disease, and insulin requirement. My assessment of the extensive data from the 1930s to 1950s found earliness of onset, duration, and insulin dose not conclusively related to offspring survival. Adding to the difficulty, disease duration and insulin dose were barely correlated, which was not always true for onset age and duration. In contrast with these negative or ambiguous relations, that between perinatal death and the quality of control of diabetes was decidedly positive.

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